Lion’s Mane polysaccharides have obvious effects in protecting gastric mucosa, anti-tumor, lowering blood lipids, and treating gastrointestinal diseases
Hericium erinaceus, a well-known dual-purpose fungus for food and medicine, is rich in protein, fat, vitamins and other nutrients. Lion’s Mane polysaccharide is the most important functional component in Hericium erinaceus. It has been found in research to protect the gastric mucosa, Enhance immunity, anti-oxidation and other functions
Hericium erinaceus polysaccharide can treat gastritis and gastric ulcer
Hericium erinaceus polysaccharide can reduce gastric acid secretion, neutralize gastric acid, and have a repairing effect on gastric mucosa.
Polysaccharides isolated from Hericium erinaceus fruiting bodies can significantly increase defense repair factors (EGF, bFGF, PGE2), reduce inflammatory cytokines (IL-1β, TNF-α) and oxidative stress factor MDA levels, and repair defenses by activating the body System, reduce inflammation and reduce oxidative damage, play a pre-protective effect on gastric mucosa.
Antitumor
The glycoprotein (HEG-5) purified from the fermented mycelium of Hericium erinaceus can induce apoptosis and cell cycle arrest of gastric adenocarcinoma cells (SGC-7901) by down-regulating the B lymphoma-2 gene (Bcl- 2) Expression of phosphatidylinositol 3-kinase (PI3K) and serine/threonine protein kinase (AKT1), up-regulation of apoptosis-related proteins (Caspase-8, Case-3), human tumor suppressor genes (p53) 2. The expression of cell division protein kinase 4 (CDK4) significantly inhibits the proliferation and colony formation of gastric adenocarcinoma cells.
Hericium erinaceus fruiting body polysaccharide can significantly enhance the programmed death of human liver cancer cells induced by doxorubicin, and can be used as a potentiator of the sensitized doxorubicin-mediated programmed cell death signal.
Lower blood sugar
The polysaccharides HIPS1 and HIPS2 extracted from Hericium erinaceus can inhibit blood urea nitrogen, aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase and creatinine levels in the serum of diabetic mice, and increase SOD and glutathione peroxidation. The activities of GSH-Px and Catalase (CAT) significantly reduce the blood sugar content in diabetic mice, showing a good blood sugar lowering effect
With the in-depth research on the unique nutritional and medicinal value of Lion’s Mane , the development of related functional products is increasing, and the market continues to expand to meet different needs of people. As one of the most important functional components of Hericium erinaceus, polysaccharides play an important role in the nutrition and health products of Hericium erinaceus.
